Exogenous glycosaminoglycans coat damaged bladder surfaces in experimentally damaged mouse bladder

Exogenous glycosaminoglycans coat damaged bladder surfaces in experimentally damaged mouse bladder

BACKGROUND Interstital cystitis is often treated with exogenous glycosaminoglycans such as heparin, chondroitin sulphate (Uracyst), hyaluronate (Cystistat) or the semi-synthetic pentosan polysulphate (Elmiron). The mechanism of action is presumed to be due to a coating of the bladder surface to replace the normally present chondroitin sulphate and heparan sulphate lost as a result of the diseas...

Regionally Enhanced Multiphase Segmentation Technique for Damaged Surfaces

Imaging-based damage detection techniques are increasingly being utilized alongside traditional visual inspection methods to provide owners/operators of infrastructure with an efficient source of quantitative information for ensuring their continued safe and economic operation. However, there exists scope for significant development of improved damage detection algorithms that can characterize ...

Mouse Bladder Tumor Antigens

Table 1 Expression of antigens defined by antibodies 3872 and 6.10 in frozen sections of tumor, as detected by immunohistology A modification of the Sternberger PAP technique (6) was used to demonstrate antigen expression in frozen sections of various tissues, as described under "Materials and Methods." The degree of staining detected was graded from (negative)through + (weakly positive) to +++...

Early Detection of Damaged Cartilage in DMM Mouse Using Nanosomes

Interstitial cystitis/bladder pain syndrome and glycosaminoglycans replacement therapy

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating chronic disease characterized by discomfort or recurrent abdominal and pelvic pains in the absence of urinary tract infections. Its symptomatology includes discomfort, increased bladder pressure, sensitivity and intense pain in the bladder and pelvic areas, increased voiding frequency and urgency, or a combination of these s...